Once you have completed the configuration of MFA settings for Outlook Anywhere application, you are ready to turn on MFA on the application.

Device-Based Outlook Anywhere MFA for Outlook for Windows

Select the "mapi" application node

Select both "Enable Two-Factor Authentication on Current Node" and "Apply Settings to Child Nodes"

Click "Apply" to apply settings.

Outlook Anywhere is now enabled with MFA.

Device-Based Outlook Anywhere MFA for Outlook for Mac

Select the "EWS" application node

Select both "Enable Two-Factor Authentication on Current Node" and "Apply Settings to Child Nodes"

Click "Apply" to apply settings.

Outlook Anywhere is now enabled with MFA.

Agent-Based Outlook Anywhere MFA for Outlook for Windows

Select the "mapi" application node

Select both "Enable Two-Factor Authentication on Current Node" and "Apply Settings to Child Nodes"

Select the "RPC" application node

Select both "Enable Two-Factor Authentication on Current Node" and "Apply Settings to Child Nodes"